BRCA1 in replication
نویسندگان
چکیده
منابع مشابه
BRCA1 in replication
O n page 693, BRCA1 branches out from its DNA repair duties. Images from Pageau and Lawrence suggest that this tumor suppressor also helps out during heterochromatin replication. Repair is the function usually ascribed to BRCA1, which accumulates at damaged DNA in irradiated cells. But undamaged cells also have nuclear BRCA1 foci. They appear mostly during S phase, but because the foci do not h...
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The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated remain unclear. Here, we describe two major fork restart pathways, and demonstrate that their selection is governed by 53BP1 and BRCA1, which are known to control the pathway choi...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1755iti5